N-BOC-4-Hydroxypiperidine Chemical Properties
| Melting point | 61-65 °C (lit.) |
| Boiling point | 292.3±33.0 °C(Predicted) |
| density | 1.107±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | Powder |
| pka | 14.80±0.20(Predicted) |
| color | White to cream |
| BRN | 7202094 |
| InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-8(12)5-7-11/h8,12H,4-7H2,1-3H3 |
| InChIKey | PWQLFIKTGRINFF-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(O)CC1 |
N-BOC-4-Hydroxypiperidine Usage And Synthesis
| Chemical Properties | White to cream powder |
| Uses | N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds. |
| Uses | Used in a synthesis of N-heterocyclic alkyl ethers via the Mitsunobu reaction. |
| Preparation | A mixture of 4-hydroxypiperidine (10.0 g, 98. 9 mmol), aqueous sodiumhydrogen carbonate (150 mL, 1 M), DI-FERT-BUTYL dicarbonate (21. 6 g, 98.9 mmol) and dichloromethane was stirred for 15 h. The phases were separated and the product (N-BOC-4-Hydroxypiperidine) was isolated as an oil in quantitative yield (19.9 g). |
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